是否为危控品： 否生产企业：MCE 密度：纯度：储存条件：见包装
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
CAS No. : 823218-99-1
MCE 国际站：SN 2
产品活性：SN 2 是一种有效的 TRPML3 离子通道激活剂，EC50 为 1.8 μM。SN 2 还是登革热病毒 2 (DENV2) 和寨卡病毒 (ZIKV) 的有效抑制剂。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：TRP Channel
In Vitro: The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel.
相关产品：Bioactive Compound Library Plus | Anti-Infection Compound Library | Membrane Transporter/Ion Channel Compound Library | Neuronal Signaling Compound Library | Mechanoreceptors Compound Library | Pain-Related Compound Library | Bisandrographolide C | TRPV1 activator-2 | SB-705498 | AMTB hydrochloride | ABT-239 | AS1269574 | Tivanisiran | RN-1747 | CEDAEVFKDSMVPGEK | Asivatrep | TRPV4 agonist-1 | GsMTx4 TFA | (E)-4-Oxo-2-nonenal | 1-Stearoyl-2-arachidonoyl-sn-glycerol | Podocarpic acid | M8-B | Pregnenolone monosulfate sodium | TRPC5 modulator-1 | Capsiate | FEMA 4809 | Capsazepine | JT010 | Umbellulone | ML-SI1 | TRPC5-IN-4 | EIPA hydrochloride | GSK2193874 | Icilin | TRPA1-IN-1 | Hydroxy-α-sanshool
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
品牌介绍:
• MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；
• 40,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
• 设有专业的实验中心和严格的质控、验证体系；
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
• 产品的生物活性多经各国客户实验验证；
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
• 专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
• 与世界各大制药公司及知名科研机构建立了长期的合作。
